The direct antioxidative and anti-inflammatory effects of peroxisome proliferator-activated receptors ligands are associated with the inhibition of angiotensin converting …
H Toba, S Miki, T Shimizu, A Yoshimura, R Inoue… - European journal of …, 2006 - Elsevier
Peroxisome proliferator-activated receptors (PPARs) are expressed on vascular tissue. To
investigate the direct vasoprotective effects of PPARγ and PPARα ligands, pioglitazone (3
mg/kg/day) and bezafibrate (10 mg/kg/day) were given by gavage to streptozotocin-induced
diabetic rats for 4 weeks. Streptozotocin (65 mg/kg, ip) significantly increased NADPH
oxidase, vascular call adhesion molecule-1 (VCAM-1), and osteopontin mRNA levels in the
aorta, as determined by reverse transcription (RT)-polymerase chain reaction (PCR) …
investigate the direct vasoprotective effects of PPARγ and PPARα ligands, pioglitazone (3
mg/kg/day) and bezafibrate (10 mg/kg/day) were given by gavage to streptozotocin-induced
diabetic rats for 4 weeks. Streptozotocin (65 mg/kg, ip) significantly increased NADPH
oxidase, vascular call adhesion molecule-1 (VCAM-1), and osteopontin mRNA levels in the
aorta, as determined by reverse transcription (RT)-polymerase chain reaction (PCR) …
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